LIVER NECROSIS FROM PARACETAMOL
نویسندگان
چکیده
منابع مشابه
Acute liver necrosis following overdose of paracetamol.
A woman aged 30, an inmate of a mental institution, was admitted to hospital two hours after ingesting at least 50 paracetamol tablets. She had been discovered while still swallowing some of the drug, and gastric lavage was carried out almost immediately. She had been under psychiatric care since adolescence and had received various drug therapies. Currently she was taking nortriptyline, 25 mg....
متن کاملLiver transplantation after paracetamol overdose.
OBJECTIVE To evaluate the role of liver transplantation after paracetamol overdose. DESIGN Prospective study of consecutive candidates for transplantation and performance of transplantation over 18 months. SETTING Liver unit, King's College Hospital, London. MAIN OUTCOME MEASURES Fulfilment of indicators of poor prognosis, selection for transplantation, transplantation, survival. RESULT...
متن کاملEffect of liposomal entrapment on the protective action of glutathione against paracetamol-induced liver necrosis.
Alling, C., Bruce, A., Karlsson, I. & Svennerholm, L. (1974) J. Neurochem. 23,1263-1270 Bridges, R. G . (1973) Comp. Biochem. Physiol. 44B, 191-203 Cotman, C., Blank, M. L., Moehl, A. & Snyder, F. (1969) Biochemistry 8,4606-4612 Crawford, M. A. & Sinclair, A. J. (1972) in Lipids, Malnutrition and the Developing Nervous System (Elliott, K. & Knight, J., eds.), pp. 267-287, Associated Scientific ...
متن کاملParacetamol, alcohol and the liver.
It is claimed that chronic alcoholics are at increased risk of paracetamol (acetaminophen) hepatotoxicity not only following overdosage but also with its therapeutic use. Increased susceptibility is supposed to be due to induction of liver microsomal enzymes by ethanol with increased formation of the toxic metabolite of paracetamol. However, the clinical evidence in support of these claims is a...
متن کاملSerum transaminase levels after experimental paracetamol-induced hepatic necrosis.
The relationship between serum transaminase levels and the extent of paracetamol-induced liver necrosis has been investigated in the rat. Three methods of histological quantitation were used to assess of necrosis--arbitrary grading, point counting, and the image-analysis computer. Highly significant correlations were obtained between the three methods and all were found to be reproducible. A cl...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology and Chemotherapy
سال: 1966
ISSN: 0366-0826
DOI: 10.1111/j.1476-5381.1966.tb01841.x